Nasal Inhalers / Mouthwash / Eye Drops

Virus Load Change

Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients

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This trial was conducted at the Department of Otorhinolaryngology, Head and Neck Surgery of the Faculty of Medicine of the University of Cologne, Germany. Outpatients visiting Corona test centres were informed about the possibility of participating in the trial. Patients aged 18 to 60 years were eligible to participate if tested positive for SARS-CoV-2 in a Corona test centre by PCR test within 48 h prior to inclusion and had to quarantine at home due to instructions of the local health authority. A complete list of inclusion and exclusion criteria is presented in Table Table1.1. Patients were visited and tested at home on regular basis by the investigators, physicians specialised in otorhinolaryngology, medical hygiene, or general medicine.

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Covid-19 Nasel Spray

Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes

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With unrelenting SARS-CoV-2 variants, additional COVID-19 mitigation strategies are needed. Oral and nasal saline irrigation is a traditional approach for respiratory infections/diseases. As a multidisciplinary network with expertise/experience with saline, we conducted a narrative review to examine mechanisms of action and clinical outcomes associated with nasal SI, gargling, spray, or nebulization in COVID-19. SI was found to reduce SARS-CoV-2 nasopharyngeal loads and hasten viral clearance. Other mechanisms may involve inhibition of viral replication, bioaerosol reduction, improved mucociliary clearance, modulation of ENaC, and neutrophil responses. Prophylaxis was documented adjunctive to personal protective equipment. COVID-19 patients experienced significant symptom relief, while overall data suggest lower hospitalization risk..

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Nose Sprays: A Last Line of Defense in a World Hellbent on Giving You Covid


In the fight against Covid (SARS-2), nose sprays haven’t gotten much attention. Everyone’s been yelling at each other about the big three: masks, vaccines, and clean air. So it’s worth asking, does any of this stuff work?

The limited data says, yesbut…

There’s hundreds of studies on the big three (masks, vaccines, clean air). By comparison, there’s only a handful of nose sprays. There’s a lot of personal testimony that they offer some protection.

There’s a few big questions: Why do we need them? How do they work? Which one works best? Are they safe for kids?

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Nasal Spray

Nasal & Throat Sprays

COVID Lists have a category for nasal and throat sprays that is current and is updated as new information becomes available. Click below to see the eight most recent bookmarked articles.

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CPC Mouthwash

CPC in mouthwashes is shown in humans to break the membrane of SARS-CoV-2 and reduce the amount of active virus in saliva

A clinical trial shows that rinsing the mouth for one minute with mouthwashes containing 0.07% Cetylpyridinium Chloride (CPC) reduces the number of infectious viruses in saliva such as SARS-CoV-2

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Lumify, Besivance shown to inactivate COVID-19

Lumify and Besivance showed complete inactivation of COVID-19 in an investigational study, researchers reported at the Ocular Microbiology and Immunology Group annual meeting.

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Effectiveness of mouthwashes on reducing SARS-CoV-2 viral load in oral cavity: a systematic review and meta-analysis

The risk of SARS-COV-2 transmission is relatively high during dental procedures. A study was conducted to investigate the effects of mouthwashes on SARS-COV-2 viral load reduction in the oral cavity.

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Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection

The COVID-19 pandemic continues to devastate communities all over the world. The aim of this study was to evaluate the efficacy and safety of the test agent as a prophylaxis against SARS-CoV-2 infection in a population of high-risk healthcare workers.

Methods The study was a multi-centre, prospective, double-blind, randomized, placebo-controlled trial. Key eligibility criteria included absence of significant co-morbidity and no previous SARS-CoV-2 infection or vaccination… 

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