Analysis of SARS-CoV-2 viral loads in stool samples and nasopharyngeal swabs from COVID-19 patients in the UAE
Overall, in this study, 42% of participants that tested positive for the virus in nasopharyngeal swabs also tested positive in stools highlighting the high rate of viral shedding in stools among COVID-19 patients and demonstrating that wastewater-based epidemiology could provide estimates of infectious cases in the population. Based on the results reported in this study, wastewater-based surveillance has the advantage of monitoring virus shedding over time from symptomatic, asymptomatic, pre-symptomatic, and post-symptomatic individuals. This approach can present valuable information on the prevalence of the virus in the community and the early detection of outbreaks. Previously, studies investigating SARS-CoV-2 detection in stool samples were qualitative and involved hospitalized and severe cases. In this study, we explored the quantitative pattern of viral shedding in mild cases and highlighted the disparity between viral shedding in stools and nasopharyngeal swabs.
A 14-day course of metformin, a common drug used to manage type 2 diabetes, prevents long COVID, according to a new study in The Lancet Infectious Diseases.
The promising results come from the COVID-OUT study, which looked at three readily available drugs: ivermectin, fluvoxamine, and metformin, for both COVID treatment and long-COVID prevention. All three drugs had shown antiviral properties in vivo against SARS-CoV-2, and all had been promising medical treatments for the virus, as they are cheap and safe.
Now, more than 2 years after the outpatients trial began, metformin is the only medical intervention in the study shown to prevent long COVID.
Outpatient treatment of COVID-19 and incidence of
post-COVID-19 condition over 10 months (COVID-OUT):
a multicentre, randomised, quadruple-blind, parallel-group,
phase 3 trial
Post-COVID-19 condition (also known as long COVID) is an emerging chronic illness potentially affecting millions of people. We aimed to evaluate whether outpatient COVID-19 treatment with metformin, ivermectin, or fluvoxamine soon after SARS-CoV-2 infection could reduce the risk of long COVID.
Outpatient treatment with metformin reduced long COVID incidence by about 41%, with an absolute reduction of 4·1%, compared with placebo. Metformin has clinical benefits when used as outpatient treatment for COVID-19 and is globally available, low-cost, and safe.
A literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus.
LitCovid is a curated literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus. It is the most comprehensive resource on the subject, providing central access to 29074 (and growing) relevant articles in PubMed. The articles are updated daily and are further categorized by different research topics and geographic locations for improved access.
Resources to help schools keep students and staff safe
The COVID Safety for Schools Course is a high-quality video-based course for Australian schools. It explains the realities of COVID in clear, easy-to-understand language and provides practical advice on how to minimise the risk of COVID spreading at schools, based on the latest science.
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction1,2,3 during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients experiencing prolonged symptoms, termed post-acute sequelae of SARS-CoV-2. However, the burden of infection outside the respiratory tract and time to viral clearance are not well characterized, particularly in the brain. Here we carried out complete autopsies on 44 patients who died with COVID-19, with extensive sampling of the central nervous system in 11 of these patients, to map and quantify the distribution, replication and cell-type specificity of SARS-CoV-2 across the human body,
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Our Mission
At the Canadian Covid Society, we strive to protect the health and safety of people in Canada against the harms of COVID-19 and long Covid, through education, engaging and empowering the public and organizations with scientific knowledge.