Covid Resources

Covid Impact of Multiple Organs

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Physiology International

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Beyond the acute illness: Exploring long COVID and its impact on multiple organ systems

The emergence of COVID-19, caused by the novel coronavirus SARS-CoV-2, has significantly impacted human health on a global scale. Since the first reported case in December 2019, the virus has spread rapidly across the globe, infecting millions of individuals and leading to widespread morbidity and mortality.

 Although COVID-19 primarily affects the respiratory system, emerging evidence indicates that it may also harm other organs, including the cardiovascular, neurological, gastrointestinal, dermatological, and renal systems, resulting in chronic complications in some people. These post-COVID-19 complications are known as long COVID or post-acute sequelae of SARS-CoV-2 infection (PASC).

Virus induced senescence

Taylor & Francis Online

EXPERT OPINION ON THERAPEUTIC TARGETS 2023, VOL. 27, NOS. 4–5, 263–267 

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Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2

The SARS-CoV-2 (COVID-19) pandemic has resulted in a severe global public health catastrophe, with COVID-19 being the 3rd largest cause of death in the U.S.A, ranked only behind heart disease and cancer. There were also significant economic costs with the measures put in place to prevent the spread of COVID-19. COVID-19 is caused by the SARS-CoV-2 virus, first identified in Wuhan, China, in late 2019. New strains have emerged throughout the pandemic that differ in transmission efficiency, virulence, and vaccine susceptibility, thus complicating the spread of the pandemic.

What SARS-CoV-2 Does to the Body

SARS-CoV-2

What SARS-CoV-2 Does to the Body (2nd Edition, July 2023)

Published by the Pandemic Accountability Index, July 7, 2023

Last November, we posted a compilation of over a hundred studies and articles on how the SARS-CoV-2 virus can harm the body. It’s been a little over six months since then, and a lot more research has been published since then. So, it’s long overdue to revisit our understanding of why it’s just so important to prevent infections from a deadly & disabling virus that has ended and upended the lives of millions around the world – in Europe alone; the WHO is saying that over 36 million are suffering from Long COVID disability, an umbrella term for numerous medical complications.

Those who have insisted that SARS-CoV-2 is relatively harmless or “mild” or insisted that COVID-19 is “just a cold/flu” should be forced to contend with the ever-growing mountain of scientific research that has emerged as new discoveries continue to be researched to this day.

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Covid and the Immune System

Covid & The Immune System

“No, we are *not* going to sling around misinformation like “immunity debt” this winter. Here are 40 sources on what covid does to your immune system”

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Infectivity of exhaled SARS-CoV-2 aerosols

Infectivity of exhaled SARS-CoV-2 aerosols is sufficient to transmit covid-19 within minutes

Six aerosol samples from three individuals were culturable, of which five were successfully quantified using TCID50. The source strength of the three individuals was highest during singing, when they exhaled 4, 36, or 127 TCID50/s, respectively.

Eyeglasses and risk of Covid-19

Eyeglasses and risk of COVID-19 transmission - analysis of the Virus Watch Community Cohort study

Highlights

  • Eyeglasses are associated with a protective effect against COVID-19
  • The protective effect was reduced if wearing glasses interfered with mask-wearing
  • There was no protective effect for those who wore contact lens
  • Still a protective association after adjusting for age, sex, occupation and income

What SARS-CoV-2 Does to the Body

What SARS-CoV-2 Does to the Body (3rd Edition, December 2023)

The Ever-Expanding Biological Minefield


With the JN.1 variant heading into 2024, with poor booster uptake and little to no masking, many Americans will be bringing home a deadly and disabling virus from their holiday celebrations and discovering their new status as a disabled person in the following months. Following up with our previous editions of this archive, from July 2023 and November 2022, this compilation of medical research on just how SARS-CoV-2 and COVID-19 harm the human body is more important now than ever.

Viral Loads in Stool Samples

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Analysis of SARS-CoV-2 viral loads in stool samples and nasopharyngeal swabs from COVID-19 patients in the UAE

Overall, in this study, 42% of participants that tested positive for the virus in nasopharyngeal swabs also tested positive in stools highlighting the high rate of viral shedding in stools among COVID-19 patients and demonstrating that wastewater-based epidemiology could provide estimates of infectious cases in the population. Based on the results reported in this study, wastewater-based surveillance has the advantage of monitoring virus shedding over time from symptomatic, asymptomatic, pre-symptomatic, and post-symptomatic individuals. This approach can present valuable information on the prevalence of the virus in the community and the early detection of outbreaks. Previously, studies investigating SARS-CoV-2 detection in stool samples were qualitative and involved hospitalized and severe cases. In this study, we explored the quantitative pattern of viral shedding in mild cases and highlighted the disparity between viral shedding in stools and nasopharyngeal swabs.

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Viral Load-Vax_vs_non-vax

Viral load in stools and nasopharyngeal swabs of unvaccinated and vaccinated (at least 1 dose) participants.

Diabetes Drug to Prevent Long Covid

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Common diabetes drug shown to prevent long COVID

A 14-day course of metformin, a common drug used to manage type 2 diabetes, prevents long COVID, according to a new study in The Lancet Infectious Diseases.

The promising results come from the COVID-OUT study, which looked at three readily available drugs: ivermectin, fluvoxamine, and metformin, for both COVID treatment and long-COVID prevention. All three drugs had shown antiviral properties in vivo against SARS-CoV-2, and all had been promising medical treatments for the virus, as they are cheap and safe.

Now, more than 2 years after the outpatients trial began, metformin is the only medical intervention in the study shown to prevent long COVID.

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